Current Issue : April - June Volume : 2019 Issue Number : 2 Articles : 8 Articles
Dangguibuxue decoction (DBD), a kind of Chinese herbal medicine, has been widely used to treat blood deficiency disease\nin China. In this experiment, we studied the effects of the Dangguibuxue decoction (DBD) on the myocardial injury induced\nby cyclophosphamide in mice. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), and\nlactic dehydrogenase (LDH) in serum were detected by commercial kits. Total white blood cell (WBCs), platelets, and cytokines\npathological changes of heart tissuewere also examined. In addition, the protein levels of theNF.................
There is an increasing need for innovative drug and prophylaxis discovery against malaria. The aim of the present study was to test\nin vivo antiplasmodial activity of Croton macrostachyus H. (Euphorbiaceae) stem bark extracts from Kenyan folkloric medicine.\nInbred Balb/c mice were inoculated with erythrocytes parasitized with Plasmodium berghei (ANKA). Different doses (500, 250,\nand 100 mg/kg) of C. macrostachyus ethyl acetate, methanol, aqueous, and isobutanol extracts were administrated either after\ninoculation (Petersâ?? 4-day suppressive test) or before inoculation (chemoprotective test) of the parasitized erythrocytes. All the\nextracts showed significant suppression of parasitemia compared to control...............
In recent years, the utilization of Chinese nativemedicine and other plant extracts in the treatment of diseases has attracted extensive\nattention, especially in the area of malignant tumors. However, lots of herbal remedies active ingredients have not been found or\nhave been discovered but not effectively developed and applied. Therefore, screening new Chinese medicine active components\nand determining their antitumor effects have become a new breakthrough in the prevention and treatment of tumor disease. In\nthe past years, a large number of studies have demonstrated that Polygonum cuspidatumand its active components like resveratrol\nshowed excellent antitumor activities, including our own antitumor studies about resveratrol in colorectal cancer.The purpose of\nthis review is to summarize the research progress of Chinese herb Polygonum cuspidatum and its active components in tumor\ndiseases and provide theoretical basis for further scientific experiments and clinical applications....
Diabetes mellitus (DM) is a serious chronic metabolic disorder. Various diseases are being treated with medicinal plants and\nthat is because of the less side effects of the current therapy. The diversity of plants in Armenia is due to the singularity of\nnatural environment. However, biochemical activity of these plants has not been studied well. Thus, the goal was to investigate\nbiochemical activity and antihyperglycemic properties of Rumex obtusifolius L. in rabbits with hyperglycemia. The high content\nof total phenolic compounds, flavonoids, and tannins has been determined in this plant extract. Oral administration of ethanol\nextract showed significant effect on hyperglycemia, reducing fasting glucose levels (57.3%, p<0.05), improving glucose tolerance, and\nincreasing liver glycogen content (1.5-fold, p<0.01) compared to the hyperglycemic control group. Furthermore, ethanol extract of\nR. obtusifolius reduced total cholesterol, low-density lipoprotein cholesterol levels, and vice versa increased high-density lipoprotein\ncholesterol levels and also decreased liver enzymes levels (alanine aminotransferase and aspartate aminotransferase) comparedwith\nuntreated group. These findings suggest that R. obtusifolius may have beneficial effects and should be supplement, as herbal remedy\nin the treatment of DM....
This study was designed to investigate the potential of Emblica officinalis, Acacia concinna, Eclipta alba, Sapindus mukorossi, Withania somnifera, Nardostachys jatamansi, Trigonella foenum-graecum, Aloe-vera extracts in the promotion of hair growth. Hair growth promoting activity of gel formulation of Emblica officinalis, Acacia concinna, Eclipta alba, Sapindus mukorossi, Withania somnifera, Nardostachys jatamansi, Trigonella foenum-graecum, Aloe-vera was studied following its topical administration. Alopecia was induced in Wistar albino female rats by subcutaneous administration of testosterone propionate (1 mg/day). The injection was given once daily 5 days a week up to 12 weeks. Evaluation of hair loss inhibition was done by topical administration of herbal extracts and monitoring various parameters like hair initiation and hair completion time, hair density, hair length, anagen/telogen (A/T) ratio and histological observation of animal skin sections. Minoxidil solution was applied topically as standard. Groups treated with gel formulation of the plant showed hair re-growth as reflected by hair initiation and completion time, hair density, hair length, anagen/telogen (A/T) ratio and skin (histopathological studies) sections. These parameters showed significant results in polyherbal gel treated group as compared to single herbal gel treated groups of Emblica officinalis, Withania somnifera, Eclipta alba, Acacia concinna, Nardostachys jatamansi, Trigonella foenum-graecum, Sapindus mukorossi and Aloe vera. Morphological and histological observations of hair growth show significant active proliferation. Gel formulation of Emblica officinalis, Acacia concinna, Eclipta alba, Sapindus mukorossi, Withania somnifera, Nardostachys jatamansi, Trigonella foenum-graecum, Aloe-vera definitely promotes hair growth by inducing anagen in telogen (resting) phase hair follicles. Animals treated with polyherbal formulation gel showed better efficacy as compared to single formulated drugs....
Inflammatory bowel disease (IBD) describes two major inflammatory disorders of gastrointestinal tract, Ulcerative colitis (UC) and Crohn’s disease (CD). The present study was designed to evaluate protective effect of methanolic extract of Luffa echinata Roxb. (MELE) fruit by using acetic acid induced IBD model in mice. Acute toxicity study was performed for MELE in Wistar rats. No signs of toxicity or mortality were observed in MELE (2000 mg/kg) treated rats. In this study, the methanolic extract was evaluated in two different doses. Those were 50 mg/ kg, p.o. and 100 mg/kg, p.o. Colitis was induced by installation of 0.1 ml of 4 % acetic acid intrarectally in each animals of all group except normal control group on 7th day. Sulafasalazine (360 mg /kg, p.o.) was used as standard. Treatments of above extracts and drug were given till 10 days. % losses in weight and stool consistency were measured throughout study period. At end of study, the inflammatory changes in colon of animals were assessed with help ofcolonmucosal damage index (CMDI), histological score andmyeloperoxidase (MPO) activity. The treatment with MELE (50 mg /kg) and (100 mg /kg) showed significant improvement in weight and decreased stool consistency. The CMDI, histological score and MPO activity were also significantly lower by MELE treatment in mice. The results of present study indicate protective effect of methanolic extract of Luffa echinata fruit in IBD might be due to its anti-inflammatory and antioxidant potential....
Tardive dyskinesia is the common extrapyramidal side effect that occurs with the chronic use of antipsychotics. In this study we used an animal model of vacuous chewing movements induced by chronic treatment with haloperidol for the assessment of protective benefit of Ganoderma lucidum, a polyphenolic richmushroom species. Ganoderma lucidum has shown various pharmacological activities that include anti-inflammatory, antitumor, antiallergic and antioxidant activities. There are several species of Ganoderma that are known for their medicinal use but Ganoderma lucidum (red Reishi) and Ganoderma sinensis (black Reishi) exhibit most beneficial health promoting properties. Here we used male albino mice that were treated with two different doses (150 and 300 mg/kg p.o.) of Ganoderma lucidum. The results of our study showed the protective benefit of Ganoderma lucidum against tardive dyskinesia by significant reduction in vacuous chewing movements (VCM’s) in both groups treated with Ganoderma lucidum extract....
Background: Ethnomedicinally, the family Polygonaceae is famous for the management of cancer. Various species of\nthis family have been reported with anticancer potentials. This study was designed to isolate anticancer compounds\nfrom ethnomedicinally important species Polygonum barbatum.\nMethods: The column chromatography was used for the isolation of compounds from the solvent fraction of P.\nbarbatum. The characterization of isolated compounds was performed by various spectroscopic techniques like UV,\nIR, mass spectrometry and 1D-2D NMR spectroscopy. Keeping in view the ethnomedicinal importance of the family,\ngenus and species of P. barbatum, the isolated compounds (1â??3) were screened for anticancer potentials against oral\ncancer (CAL-27) and lungs cancer (NCI H460) cell lines using MTT assay. Active compound was further investigated for\napoptosis by using morphological changes and flow cytometry analysis. In vivo anti-angiogenic study of the isolated\ncompounds was also carried using chorioallantoic membrane assay. Docking studies were carried out to explore the\nmechanism of anticancer activity.\nResults: Three dihydrobenzofuran derivatives (1â??3) have been isolated from the ethyl acetate fraction of P. barbatum.\nThe structures of isolated compounds were elucidated as methyl (2S,3S)-2-(3,4-dimethoxyphenyl)-4-((E)-3-ethoxy-\n3-oxoprop-1-en-1-yl)-7-methoxy-2,3-dihydrobenzo-furan-3-carboxylate (1), (E)-3-((2S,3S)-2-(3,4-dimethoxyphenyl)-\n7-methoxy-3-(methoxy carbonyl)-2,3-dihydrobenzofuran-4-yl)acrylic acid (2) and (2S,3S)-4-((E)-2-carboxyvinyl)-...
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